Limits of homology detection by pairwise sequence comparison
نویسندگان
چکیده
منابع مشابه
Limits of homology detection by pairwise sequence comparison
MOTIVATION Noise in database searches resulting from random sequence similarities increases as the databases expand rapidly. The noise problems are not a technical shortcoming of the database search programs, but a logical consequence of the idea of homology searches. The effect can be observed in simulation experiments. RESULTS We have investigated noise levels in pairwise alignment based da...
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Weak Homology Detection by Profile-Profile Comparison
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2001
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/17.4.338